Quarterbacks

Patrick Mahomes ($8,300)
Patrick Mahomes has been a fantasy football superstar, and Week 2 presents an ideal opportunity for him to shine. He’s known for his deep passes, and since Week 12 of last season, he leads the NFL in completions of 20+ yards. This week, he faces the Jaguars, who allowed 24 completions of 20+ yards to QBs during the same period. The Chiefs are favored, and this game has the highest total on the slate. Mahomes is a must-have in your lineup if his favorite target, Travis Kelce, is back in action. Expect him to put up big numbers in what could be a shootout this week.

Josh Allen ($7,9000)
Josh Allen had a tough outing in Week 1 against the Jets, but don’t let that deter you. He’s facing the Raiders in Week 2, a defense that allowed the fourth-most passing yards in 2022 and tied for the fewest interceptions. Allen is a dual-threat QB with rushing upside, and he’s motivated to bounce back after a disappointing season opener. The Bills have the highest implied team total on the main slate, making Allen an attractive option with both a high floor and ceiling. Look for him to rebound in a favorable matchup this week.

Trevor Lawrence ($6,700)
Trevor Lawrence showed promise last year, especially in the red zone, where he boasts the best passer rating among QBs in his last eight games. He’ll need to throw often to keep up with the Chiefs, making him an intriguing play. His connection with Calvin Ridley looked strong in Week 1, and Ridley is a top stacking option. Lawrence should be in line for a high-paced game with plenty of passing opportunities. Consider stacking him with Ridley or Zay Jones for potential fantasy goodness.

Joe Burrow ($6,900)
Joe Burrow had a rough Week 1, but he was likely rusty due to a preseason calf injury and poor weather conditions. However, he gets a bounce-back opportunity against the Ravens, a defense that has allowed QBs to shine in recent games. Burrow has an impressive passer rating since the start of the 2021 season and could deliver a solid performance if key Ravens defenders are out.

Brock Purdy ($5,700)
Brock Purdy surprised everyone with his Week 1 performance, proving he’s a capable NFL QB. Facing the Rams, who are not the dominant defense they once were, Purdy has the potential for another strong outing. He’s thrown 2+ passing TDs in his last seven games and could take advantage of the Rams’ defense that allowed 2+ passing TDs to QBs in 38% of their games. Purdy is a value play with upside.

Running Backs

Josh Jacobs ($7,100)
Josh Jacobs didn’t quite meet expectations in his last outing, but he faces a favorable matchup against the Bills, who struggled against the run last week, allowing 172 rushing yards. Jacobs is a powerful runner, and he’s averaged an impressive 102.4 rushing yards per game over his last eight contests. The Bills have allowed an average of 127.6 rushing yards per game to running backs during the same period. Jacobs is a workhorse and can produce in various game scripts. Given the Bills’ struggles against the run, he’s an appealing option in Week 2.

Joshua Kelley ($5,000)
Joshua Kelley made a statement in Week 1 with 91 rushing yards and a touchdown on 16 carries. He showcased his efficiency, averaging 5.7 yards per carry, and could be a valuable asset in fantasy leagues. While he’s behind Austin Ekeler on the depth chart, Kelley’s performance earned him attention. If Ekeler is unable to play, Kelley could step into the starting role. Keep an eye on Ekeler’s status as it will impact Kelley’s value.

James Conner ($6,200)
James Conner has been a consistent performer, averaging 91.7 rushing yards per game since Week 12 of last season. He faces the Giants, who have struggled against the run, allowing an average of 136.1 rushing yards per game to running backs during the same period. Conner played 84% of the snaps in Week 1, totaling 19 touches and 70 total yards. While he didn’t break many tackles, he should see ample opportunities to produce in Week 2.

Travis Etienne Jr. ($6,900)
Travis Etienne had an impressive Week 1, playing 80% of the snaps and racking up 104 yards and a touchdown on 23 touches. He’s clearly the workhorse for the Jaguars and offers value with his passing game involvement. Facing the Chiefs in a potential shootout, Etienne looks script-independent and could have a significant role in both the running and passing game. With a high over/under, he’s a strong option for your lineups.

Christian McCaffrey ($8,900)
Christian McCaffrey is a fantasy football star and had a heavy workload in Week 1, even in a blowout. He’s averaged 20.6 fantasy points per game over his last eight contests, showcasing his elite status among running backs. The Rams’ defense has allowed an average of 23.7 fantasy points per game to opposing running backs during the same period. While McCaffrey comes with a high salary, his ability to contribute both on the ground and through the air makes him a worthy investment.

Tony Pollard ($7,500)
Tony Pollard has been a touchdown machine, with eight TDs since Week 12 of last season. The Jets’ defense, however, has been stingy, allowing an average of just 0.2 TDs per game to running backs during the same period. Pollard played 64% of the snaps in Week 1, showing his involvement in the offense. He’s a top-five RB option weekly and could find success even in a tough matchup.

Saquon Barkley ($8,000)
Saquon Barkley and the Giants are looking to bounce back after a tough Week 1 loss. Facing the Cardinals, who have their own struggles, Barkley could be a key factor. He’s a versatile back who can contribute both as a runner and receiver. With the Giants expected to control time of possession, Barkley has an opportunity to make an impact in Week 2.

Rachaad White and David Montgomery 
Rachaad White faces a tough Bears defense that has limited opposing RBs. In contrast, David Montgomery offers potential in the passing game against the Seahawks, who have allowed receptions to running backs. Keep an eye on their roles within their respective offenses as they could provide value in certain game scripts.

Wide Receivers

Amon-Ra St. Brown ($7,800)
Amon-Ra St. Brown had a solid Week 1 performance, catching 6 of 9 targets for 71 yards and a touchdown. He’s facing a defense that struggled against wide receivers last week, and St. Brown has been a reliable target, with 61 receptions since Week 12 of last season. While the Seahawks’ defense has improved, St. Brown’s home-field advantage and his ability to rack up receptions make him an appealing choice for your lineups.

Stefon Diggs ($8,000)
Stefon Diggs proved his mettle in a tough matchup against the Jets, recording 10 catches for 102 yards and a touchdown. Facing the Raiders in Week 2, he’s in a more favorable situation, as the Raiders allowed the fourth-most passing yards in 2022. Diggs is the primary target for Josh Allen and is capable of big performances. Consider him a strong option in Week 2.

Calvin Ridley ($7,200)
Calvin Ridley didn’t show any signs of rust in Week 1, posting eight receptions for 101 yards and a touchdown. He’s the clear WR1 for the Falcons and has established a strong rapport with quarterback Trevor Lawrence. Ridley’s usage across the field makes him a versatile threat. In a game that could turn into a shootout against the Chiefs, Ridley has the potential for another impressive performance.

Ja’Marr Chase ($7,900)
Ja’Marr Chase may have had a quieter Week 1, but he’s still a dynamic talent with big-play potential. He caught 5 of 9 targets for 39 yards in Week 1 vs the Browns as the Bengals could only muster 3 points. Facing the Ravens, who have allowed 140.0 receptions to wide receivers since Week 12 of last season, Chase has the opportunity to make a big impact. As a key weapon in Cincinnati’s passing attack, he’s always a threat to break out for a big game.

Davante Adams ($7,600)
Davante Adams is dealing with some injuries, but with Jakobi Meyers potentially unavailable, Adams could see increased targets. In Week 1, he had 9 targets, catching 6 of them for 66 yards. Adams has been one of the most productive wide receivers in recent years, with 358 receptions since the start of the 2020 season. While the Bills’ defense is strong, Adams’ talent and potential for red-zone targets make him a valuable option.

Nico Collins ($4,800)
Nico Collins may not be the most obvious choice, but he offers value with his salary. In Week 1, he had six receptions for 80 yards on 11 targets. Rookie quarterbacks often rely on specific targets, and at 6-foot-4, Collins could serve as a security blanket. Facing the Colts, who have allowed an average of 1.6 TDs per game to wide receivers since Week 12 of last season, Collins could be a sneaky play.

Deebo Samuel ($5,600)
Deebo Samuel had a quiet Week 1, but even in a blowout, he remained involved, catching all 5 of his 7 targets for 55 yards and adding 2 rushes for 8 yards. Samuel’s ability to gain yards after the catch makes him a dynamic threat. Facing the Rams, he has the potential to make big plays and could be an important part of the 49ers’ passing game. If you believe the 49ers bounce back, consider Samuel in your lineups.

Keenan Allen and Mike Williams
With Austin Ekeler‘s availability uncertain, Keenan Allen and Mike Williams could see increased targets. Allen had a solid Week 1, catching 6 of his 9 targets for 76 yards. Facing a tough run defense in the Titans, the Chargers might lean more on the passing game. Mike Williams also has touchdown potential, with 19 TDs since the start of the 2020 season. Both wide receivers are in positions to contribute significantly if Ekeler is limited or misses this week.

Tight Ends

Travis Kelce ($7,600)
Travis Kelce is THE premier tight end option, and his return to practice suggests he’ll play in Week 2. With the Chiefs’ wide receivers facing some struggles, Kelce will be Patrick Mahomes‘ go-to target. His history of being a reliable safety blanket for Mahomes makes him an attractive option. Kelce’s potential for a monster game against the Jaguars makes him a strong choice for DFS lineups, especially in game stacks this week.

Tyler Higbee
Tyler Higbee has been consistent, averaging 8.9 fantasy points per game over his past four outings. He faces the 49ers, who have struggled against tight ends recently, allowing an average of 8.5 fantasy points per game. While Higbee might not be a superstar option, his reliability and favorable matchup make him a valuable consideration.

Darren Waller
Darren Waller is known for making big plays, with 9 receptions of 20+ yards since Week 12 of last season, the most among tight ends. Although he faces the Cardinals, who have been decent against tight ends, Waller’s ability to stretch the field and create explosive plays keeps him in consideration. If you’re looking for a high-upside option, Waller could deliver.

Zach Ertz
Zach Ertz had an unusual Week 1 performance, seeing 10 targets but converting them into only six catches for 21 total yards. However, in a position often lacking depth, volume is crucial. Ertz is relatively cheap on DraftKings and could provide value if he continues to see a significant target share in the Cardinals’ offense.

Logan Thomas
Logan Thomas was a favorite target for Sam Howell in Week 1, finishing with eight looks and four catches for 43 yards. While not a flashy option, Thomas comes at a low price and can help fill out your DFS lineups. His consistent involvement in the passing game makes him a viable budget-friendly choice.

Defenses

Cowboys
The Cowboys’ defense had a remarkable Week 1 performance, recording seven sacks, two interceptions, and scoring on both defense and special teams in a 40-0 shutout victory over the Giants. Facing the Aaron Rodgers-less New York Jets in Week 2, this defense has the potential to disrupt their opponent once again. With their ability to generate turnovers and score points, the Cowboys’ D/ST is an intriguing option.

49ers
The 49ers’ defense dominated in Week 1, notching five sacks and two interceptions while holding the Steelers to just seven points. They limited the Steelers to 273 total offensive yards. In Week 2, they face the Rams in a divisional road contest. If they can replicate their Week 1 success, they’ll be a strong DFS play against the Rams.